oh high there
oh high there
Bioavailability is defined by the degree and rate at which a substance (such as cannabinoids) is absorbed into the body. It refers to the percentage or portion of a dose of a drug or chemical that actually reaches the bloodstream to provide real benefit
A proper understanding of the topic of the bioavailability of cannabinoids requires basic knowledge of how cannabinoids are absorbed by the body. Cannabinoids and terpenes plug into special cellular receptors in the body within a system called the endocannabinoid system (ECS).
The ECS features two types of cellular receptors: CB1 and CB2. The CB1 variety is found within the brain and central nervous system, whereas CB2 receptors are located in the glands and tissues of the immune system, including primary lymphoid organs such as the thymus and bone marrow and includes secondary lymphatic tissues such as the spleen, tonsils, lymph nodes, adenoids, skin, and liver.
THC and CBD, are both absorbed by CB1 receptors and, thus, allowed to cross the extremely selective blood/brain barrier.
Bioavailability by Consumption Method
Bioavailability can vary significantly from one cannabis consumer to another. Individual characteristics such as age, gender, weight, overall health, and use of other medications all affect bioavailability, sometimes in a major way.
Cannabinoids such as CBD and THC can be consumed via a wide variety of methods, all of which provide very different levels of bioavailability.
Tinctures are concentrated liquid extractions of cannabis (usually sold in an oil) that are typically sublingually administered (via a dropper or spray). Tinctures have a widespread reputation for providing the best bioavailability (better than smoking, vaporization, and even edibles).
It should be noted that a tincture can easily be consumed via two separate consumption avenues in the human body:
Sublingual consumption offers an onset time of approximately 15 to 20 minutes, whereas ingestion and subsequent metabolization by the stomach and liver require 45 minutes to two hours for the onset of effects.
For decades, cannabis experts have advocated the use of vaporization, or vaping, instead of the smoking of dried cannabis flower or concentrates for a variety of health reasons. Not only is the vaping of cannabis flower or concentrates healthier because it produces no known carcinogens, but also because it features a much greater bioavailability.